Hi Liza – I personally haven’t done it but I don’t know why you couldn’t. You would have to be careful with your sett but if you can wrap a ruler to determine your sett with both yarns, you would get a starting point. Why don’t you try with a small warp with enough yardage to create a good-sized sample? That way you can play with different wefts and resley the reed to try different setts. Keep us posted!